Throughout their career, the Meters were always led by Art Neville (keyboard, vocals), one of the leading figures of the New Orleans musical community. As a teenager in high school, he recorded the seminal "Mardi Gras Mambo" with his group, the Hawketts, for Chess Records. The exposure with the Hawketts led to solo contracts with Specialty and Instant, where he released a handful of singles that became regional hits in the early '60s. Around 1966, he formed Art Neville and the Sounds with his brothers Aaron and Charles (both vocals), guitarist Leo Nocentelli, drummer Joseph "Zigaboo" Modeliste and bassist George Porter. The band grew out of informal jam sessions the musicians held in local New Orleans nightclubs. After spending a few months playing under the Sounds name, producer Allen Toussaint and Marshall Sehorn hired the group -- without the vocalists -- to be the house band for their label Sansu Enterprises.

As the house band for Sansu, the Meters played on records by Earl King, Lee Dorsey, Chris Kenner and Betty Harris, as well as Toussaint himself. They also performed and recorded on their own, releasing danceable instrumental singles on Josie Records. "Sophisticated Cissy" and "Cissy Strut" became Top Ten R&B hits in the spring of 1969, followed by the number 11 hits "Look-Ka Py Py" and "Chicken Strut" a year later. The Meters stayed at Josie until 1972, and during that entire time they reached the R&B Top 50 consistently, usually placing within the Top 40. In 1972, the group moved to Reprise Records, yet they didn't sever their ties with Sansu, electing to keep Toussaint as their producer and Sehon as their manager. Ironically, the Meters didn't have nearly as many hit singles at Reprise, yet their profile remained remarkably high. If anything, the group became hipper, performing on records by Robert Palmer, Dr. John, Labelle, King Biscuit Boy and Paul McCartney. By the release of 1975's Fire on the Bayou, the Meters had a Top 40 hit with Rejuvenation's "Hey Pocky A-Way" (1974), and they had gained a significant following among rock audience and critics. Fire on the Bayou received significant praise, and the group opened for the Rolling Stones on the British band's 1975 and 1976 tours.

During 1975, the Meters embarked on the Wild Tchoupitoulas project with Neville's uncle and cousin George and Amos Landry, two members of the Mardi Gras ceremonial black Indian tribe, the Wild Tchoupitoulas. The Meters, the Landrys and the Neville Brothers -- Aaron, Charles, Art and Cyril -- were all involved in the recording of the album, which received enthusiastic reviews upon its release in 1976. Cyril joined the Meters after the record's release. Despite all of the acclaim for The Wild Tchoupitoulas, its adventurous tendencies indicated that the group was feeling constrained by its signature sound. Such suspicions were confirmed the following year, when they separated from Toussaint and Sehorn, claiming they needed to take control of their artistic direction. Following the split, the Meters released New Directions in 1977, but shortly after its appearance, Toussaint and Sehorn claimed the rights to the group's name. Instead of fighting, the band broke up, with Art and Cyril forming the Neville Brothers with Aaron and Charles, while the remaining trio became session musicians in New Orleans. Modeliste, in particular, became a well-known professional musician, touring with the New Barbarians in 1979 and moving to LA during the '80s.

The Meters reunited as a touring unit in 1990 with Russell Batiste taking over the drum duties from Modeliste. Four years later, Nocentelli left the band, allegedly because he and Art Neville disagreed whether the band should be paid for samples hip-hop groups took from their old records; he was replaced by Brian Stoltz, who had played with the Neville Brothers. The Meters continued to tour throughout the '90s.